NIMG-70. MAGNETIC RESONANCE HYPOXIA IMAGING FOR RADIATION TREATMENT GUIDANCE IN GLIOBLASTOMA MULTIFORME - A DIAGNOSTIC/PROGNOSTIC CLINICAL IMAGING STUDY

Abstract Local recurrence in glioblastoma (GBM) patients is caused by the ability of tumour cells to develop treatment resistance mechanisms. Hypoxia, which present subregions GBM tumours, leading cause radiotherapy and associated with worse clinical outcomes GBM. Current standard care does not account for hypoxia. The image hypoxia at various stages offers opportunities personalise improve patients. Preoperative imaging opportunity supramarginal resections surgical planning beyond current neurosurgical guidelines. Imaging prior enables selective dose escalation strategies radioresistant regions, increasing likelihood local control. Identifying hypoxic regions harbouring progression follow up key intervening an early stage personalising therapy tailored response treatment. routine practice challenging, as it requires 18FMISO PET, available most centres. In this study, we aim investigate role oxygen enhanced (OE) blood-oxygen level dependent (BOLD) MRI biomarkers Aiming recruit 20 patients, study involves addition OE/BOLD PET several timepoints during course primary objective map on preoperative scans using ground truth. Secondary objectives include evaluating dose-painting assessment Overall, validating ought provide a non-invasive more accessible means effective, personalised